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Citrulline Malate for Heart & Vascular Health

Citrulline Malate for Heart & Vascular Health

Citrulline is a far better way of generating L-Arginine than using L-Arginine itself, which is the precursor amino acid leading to the formation of Nitric Oxide (NO).

Nitric Oxide (NO) is a powerful vasodilator, i.e. it widens the diameter of blood vessels allowing more blood to be transported through a wider channel and this, in turn, allows more oxygen and nutrients to be delivered to tissues such as the heart or skeletal muscle with exercise.

So why take Citrulline rather than L-Arginine? The reason is that L-Arginine is absorbed in the gastrointestinal tract and then transported to the liver where it undergoes rapid first-pass metabolism to other compounds leaving very little for the body to produce Nitric Oxide (NO)1.

Citrulline is essentially a ‘masked form‘ of L-Arginine1. It is absorbed from the bloodstream and then transported to the kidneys where it is then converted to L-Arginine and distributed directly into the bloodstream to be used by muscles, tissues and blood vessels including the penile artery in men with erectile dysfunction.

References:

  1. Curis, E., et al. (2005). “Almost all about citrulline in mammals.” Amino Acids 29(3): 177-205.
  2. Pizzorno, L. (2010). “Restoring Erectile Function (Viagra Doesn’t).” Longevity Medicine Review. Retrieved 11.02.2018, 2018.