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The supplement guide
Anti-Inflammatory Panel
Glutathione Generation
High DHA + Choline
EFA + DHA + GLA
The Opti D3 & K2 formulation has a synergistic blend of 1000 IU’s of Vitamin-D3 and the highly bioavailable form of Vitamin-K2 called MK7
N-Acetyl Cysteine
Inflammation is produced by poor diets, chronic disease, obesity esp. central adiposity (visceral fat) and a poor intake of phytochemicals and Omega-3 essential fatty acids. It is also a part of the ageing process due to many factors. Inflammation drives many diseases and in fact is the foundation problem of many disease states including cancer.
NAC increases a powerful antioxidant called Glutathione and this is your body’s own widely available antioxidant that mops up free-radicals and other Reactive Oxygen Species (ROS) which are cell-damaging molecules caused by metabolism, infection or injury.
So NAC in fact simply helps to generate your own antioxidant supply by providing the raw material your body needs in the form of the sulphur-containing amino acid Cysteine. but there is growing evidence that NAC may work beyond the generation of Glutathione4.
NAC works in the following ways4:
- Decreases inflammatory cytokines
- Increases Growth Factors
- Increases Neurite (nerve projections) formation through compounds like BDNF (Brain-derived neurotrophic factor)
- Decreasing oxidative (inflammatory) stress to cells, tissues, organ systems, the brain and nerve cells
- Neurotransmitter modulation
- Supporting biotransformation pathways in particular the Phase-II pathway to neutralise a vast number of toxic compounds in the body produced by the body itself or through the environment.
These are all vital cellular, organ and neuroprotective effects. It is no wonder that NAC is showing great promise in psychiatric diseases and neurodegenerative disorders.
Omega-3’s that include DHA/EPA/ALA are critical for not only dampening down inflammation but also providing the structural integrity to cell membranes and supporting receptor sensitivity and many other functions.
Omega-3’s are not something to be taken lightly for long-term health benefits. The trick is the use of Omega-3’s long-term and not to use this in a pharmacological magic-bullet sense to reverse decades of neglect. This is the folly of medical science trying to use nutrition in a heroic (pharmaceutical) way in clinical care. Nutrition does not work like an accident and emergency drug!
DHA is a vital component of the central nervous system making up 40% of the polyunsaturated fats of the brain and 60% of the retina1. This is why Omega-3 supplements rich in DHA are so critical during pregnancy and foetal brain formation.
This huge makeup of DHA in neurological tissue should raise alarm bells that if this is deficient in nerves and nerve cells, that there will be a price to pay. The whole body has cells with membranes that need Omega-3’s for cell membrane fluidity, cell receptor responsiveness, and critically for cell signalling to occur effectively.
From tissue damage to trauma to ongoing diet-related insults to the body via oxidative stress, glycation, poor antioxidant intake, reduced phytochemical intakes and exposures to environmental and toxic food compounds (herbicides, pesticides, phthalates, heavy metals, air pollution, toxicities in the home and many other threats). Omega-3’s are needed to fight off the damaging effect of inflammation and this fact cannot be disputed. Nobel Prizes have been awarded galore for Omega-3 research.
DHA: The Cochrane Collaboration finding on premature births
An unchallengeable fact is that life depends on your nutrition adequacy.
An amazing study by the Cochrane Collaboration a highly respected charitable organisation the looks objectively at medical research to reject non evidence-based ideas in the medical profession found that out of 70 randomised trials involving 20,000 women that DHA can reduce early preterm birth by 42% and by preterm birth overall by 11% an amazing result if you look at premature birth as a leading global cause of death and disability and a direct cause of more than 85% of perinatal deaths3. DHA helps with premature deaths through many mechanisms which share a commonality with neuroprotection or cellular integrity and protection of all cells, tissues and organs.
With such scientific evidence, it is imperative for medical practitioners to discuss these findings with women who are wanting to fall pregnant, especially when medical science trumpets evidence-based medicine as the gold standard for treatment.
So you can see the fantastic benefits of Omega-3’s and Choline and that these compounds need to be seriously considered in managing not only the brains of the mother and developing foetus and to prevent premature birth, but to use Omega-3’s and Choline in neurological disease and better still, to use this long before the manifestation of neurological disease starts.
Choline: The Cholinergic Anti-Inflammatory Pathway
Choline is a compound like DHA is essential in your diet. Choline is vital for cell integrity and cell signalling. Of critical importance is the Vagus nerve in dampening down systemic inflammation11. This nerve depends upon Acetylcholine which in turn depends on an adequate supply of Choline in the diet.
We now know of the ‘Inflammatory Reflex’ where the brain detects an increase in pro-inflammatory cytokines and this, in turn, causes stimulation of the vagus nerve to dampen down cytokine release from macrophages in the spleen12,13. That the brain can dampen down inflammation through a nerve is an astounding finding and groundbreaking research. All of this depends on you getting an adequate supply of Choline often lacking in Western Diets.
In 2019/2020 humanity, was introduced to SARS-CoV-2 (COVID-19) and a significant cause of death was a Cytokine Storm where a massive release of inflammatory cytokines caused death. This cytokine storm also occurs in seasonal flu. A lack of Omega-3’s, Choline and a multitude of other critical micronutrients in depleted Western diets will have caused ‘Sitting Ducks‘ in such a pandemic.
Choline is such as cheap essential nutrient and the ‘Elephant-in-the-room’ as a cause of lethal adverse effects of infections, and many disease processes is the Western diet riddled with inadequacies and ignorance, and yet medical science will look for a molecular mechanism with the ignorant belief that these cellular mechanisms are independent of dietary factors.
Two major phospholipids that are vital for cell membranes are phosphatidylcholine and sphingomyelin. Choline is needed to synthesise these components that enable cells to function.
The cell membrane is not only critical for cell-to-cell communication but for cell surface to cell interior communication through receptor activation by hormones, cytokines etc.
Choline is also vital in the creation of the neurotransmitter Acetylcholine, which is a target for Alzheimer’s treatments but when will medical science ever think of using the foundational molecule Choline to actually create Acetylcholine?
DHA – EPA – GLA
These anti-inflammatory components work synergistically with the DHA + Choline product above
This helps to balance the essential fatty acids by providing more EPA, some DHA and importantly GLA which is an Omega-6 compound with anti-inflammatory properties
Ensuring your cells have the right Omega-6 to Omega-3 ratio is vital to prevent an inflammatory overreaction to a threat.
A multivitamin, multimineral, and trace element formulation
Strong estrogens have an adverse effect in both men and women.
In women with Endometriosis, these potent estrogens can drive this endometriosis even further to cause significant pain and menstrual dysfunction.
In men, estrogen can cause adverse effects on the prostate, including the potential to cause DNA mutations and cancer, epigenetic changes, inflammation and hypertrophy (enlargement) of the prostate15.
Research galore has shown the benefit of cruciferous vegetable intake and this has an inverse effect with many common cancers. In other words, the more of these vegetables you consume that include Kale, Broccoli, Cauliflower, Broccoli Sprouts, Brussels Sprouts, there seems to be a protective effect on many cancers.
DIM has been shown in a multitude of research articles to help decrease the effect of strong estrogens by converting 17ß-Estradiol, a strong estrogen to weaker 2-hydroxyestradiol (2HE2) and 4-hydroxyestradiol (4HE2) forms of estrogen.
DIM decreases the production of a very powerful 16a-hydroxyestrone (16HE1) form of estrogen that has strong cell proliferative effects on tissues like the breast, prostate and endometrial tissue. This 16a-hydroxyestrone (16HE1) biotransformation product, is an irreversible form, and preventing or decreasing this powerful 16HE1 estrogen from being created through the action of DIM makes great sense. Science-based measures you can incorporate in your management of Endometriosis.
Estrogen affects both men and women. We know that estrogen over the lifetime of a woman is a cumulative risk for breast cancer. It also drives endometriosis in young women and prostate disease in men.
A good Multivitamin and Mineral Supplement: Filling in the Gaps
As I have made it known on this website, I find right-wing views on supplementation to be inane. The Western diet is riddled with inadequacies and to ask someone to eat a “balanced diet” in a world full of fast foods full of inadequacies and where over 60% of a population are overweight or obese and where over 95% don’t get anywhere near the intake of nutrient-rich, phytochemical-rich, and fiber-rich fruit or vegetables is obviously living in an alternative universe. This is dangerous stupidity.
This stupidity has resulted in an obesogenic society where people are nutrient-depleted and where these individuals are in the crosshairs of viruses like COVID-19.
This idiotic idea that a pharmaceutical can fix lifelong diet-lifestyle related diseases is an absolute nonsense that will undoubtedly kill the doubters who think a magic-bullet will fix a lifetime of sloth and dietary neglect.
Rigid statements are of no use to anyone in the real world.
Of growing concern now is the Triage Mechanism of nutrient insufficiency as mentioned above that may lead to a weakening of the body and impaired DNA repair processes, putting an individual at risk of cancer10. This triage mechanism is essentially robbing Peter to pay Paul, i.e. a shuffling of micronutrients from non-vital to vital organs enabling an individual to survive longer but in a weakened state.
For you, taking an excellent practitioner-only multivitamin every 2nd day will ‘fill in the gaps’ as stated by Harvard University and will help to ensure all your cellular biochemical and molecular systems function optimally. If your cells don’t function well, your tissues and organ systems become dysfunctional.
Intermittent Fasting or Intraday Fasting
As Australia’s Professor David Sinclair who holds a chair at the University of NSW Australia and Harvard University, states in his amazing book Lifespan17 – the only way to live a long and health life is to “eat less” . However eating less to live longer means you should not suffer from malnutrition in the process.
It is a fine-line between healthy fasting and suffering from malnutrition and this needs to be guided by a highly qualified Dietitian the kind this website can supply. Intermittent fasting is a well established and rigorously tested scientific principle that decreases a multitude of negative metabolic effects. But to practice intermittent fasting without damage, you need to ensure you get enough amino acids (protein) and all the vitamins, minerals, trace elements and essential fatty acids your body needs to be in an optimal cellular and metabolic state.
Heart Health and Blood Circulation
L-Citrulline: Effectively boosting Nitric Oxide (NO) to dilate blood vessels
The amazing L-Citrulline molecule provides far more L-Arginine than taking L-Arginine itself. Why? It is all about how these amino acids are absorbed and metabolised. L-Arginine is avidly taken up by the liver where the majority is converted to urea and ornithine leaving precious little for Nitric Oxide (NO) production.
L-Citrulline on the other hand is absorbed and taken to the kidneys where it is converted to L-Arginine and delivered directly into the blood stream thus by-passing the first-pass liver metabolism leading to much higher levels of L-Arginine systemically. This enables Nitric Oxide (NO) to be produced at optimal levels for blood vessel dilation and increased blood flow.
Erectile Dysfunction (ED) often accompanies diabetes or those suffering from cardiovascular disease. L-Citrulline is a great adjunctive management strategy for ED and in particular to use L-Citrulline if you are taking Viagra® or Cialis®. The sad part of this story is that the vast majority of doctors and specialists do not realise that for PDE5 Inhibitors to work they require Nitric Oxide which the PDE5 inhibitors don’t produce. Without Nitric Oxide these medications function poorly and can often fail.
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Vitamin-K2 and the diversion of calcium away from the damaged penile area
The damaged penile area can be infiltrated with calcium as this seems to be nature’s way of helping to either dampen down the inflammatory process or to stabilise the plaque. However, as is the case of many processes in the body, this healing process may be taken to a point not intended by nature and this is most likely due to the poor levels of Vitamin-K2 in most individuals consuming the Western diet.
In humans, the consumption of Vitamin-K1 in dark green leafy vegetables is converted by organisms in the gut microbiome to Vitamin-K2 but with a markedly decreased intake of vegetables and hence Vitamin-K1 the Vitamin-K2 is going to be very low and without Vitamin-K2 the ‘Calcium Cop’ that directs calcium away from soft tissues to bones then we are going run into abnormal calcification in damaged tissue.
Armed with the information above, it doesn’t take a genius to work out if around 95% of Western populations don’t get anywhere near the 5 servings of vegetables and 2 servings of fruit that Vitamin-K2 levels are going to be severely affected.
Click here to see how Vitamin-K2 in particular the MK7 form can help you.
MITOCHONDRIA AND CELL ENERGY PRODUCTION
- Singh, M. (2005). “Essential fatty acids, DHA and human brain.” Indian Journal of Pediatrics 72(3): 239-242.
- Sanders, L.M. and Zeisel, S.H., 2007. Choline: dietary requirements and role in brain development. Nutrition today, 42(4), p.181.
- Middleton, P., Gomersall, J.C., Gould, J.F., Shepherd, E., Olsen, S.F. and Makrides, M., 2018. Omega‐3 fatty acid addition during pregnancy. Cochrane Database of Systematic Reviews, (11).
- Dean, O., Giorlando, F. and Berk, M., 2011. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. Journal of psychiatry & neuroscience: JPN, 36(2), p.78.
- Imai, S.-i. and L. Guarente (2014). “NAD+ and sirtuins in aging and disease.” Trends in cell biology 24(8): 464-471.
- Bonkowski, M. S. and D. A. Sinclair (2016). “Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.” Nature Reviews Molecular Cell Biology.
- Hao, J., Ni, X., Giunta, S., Wu, J., Shuang, X., Xu, K., Li, R., Zhang, W. and Xia, S., 2020. Pyrroloquinoline quinone delays inflammaging induced by TNF‐α through the p16/p21 and Jagged1 signalling pathways. Clinical and Experimental Pharmacology and Physiology, 47(1), pp.102-110.
- Dibaba, D., et al. (2015). “Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study.” British journal of cancer.
- https://www.hsph.harvard.edu/nutritionsource/multivitamin/
- Ames, B. N. (2006). “Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.” Proceedings of the National Academy of Sciences 103(47): 17589-17594.
- Rosas‐Ballina, M. and Tracey, K.J., 2009. Cholinergic control of inflammation. Journal of internal medicine, 265(6), pp.663-679.
- Pavlov, V. A. and K. J. Tracey (2012). “The vagus nerve and the inflammatory reflex—linking immunity and metabolism.” Nature Reviews Endocrinology 8(12): 743.
- Bullmore, E., 2018. The inflamed mind: a radical new approach to depression. Picador.
- Lund, E. K., et al. (1999). “Effects of dietary fish oil supplementation on the phospholipid composition and fluidity of cell membranes from human volunteers.” Annals of Nutrition and Metabolism 43(5): 290-300.
- Nelles, J.L., Hu, W.Y. and Prins, G.S., 2011. Estrogen action and prostate cancer. Expert review of endocrinology & metabolism, 6(3), pp.437-451.
- Fahey, J.W. and Talalay, P., 1999. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food and Chemical Toxicology, 37(9-10), pp.973-979.
- Sinclair, D.A. and LaPlante, M.D., 2019. Lifespan: Why We Age—and Why We Don’t Have To. Atria Books.
