Endometriosis – Driven by Estrogen
Estrogen is the driver of Endometriosis. Normal endometrium has no aromatase activity 274 but endometrial cells that spread beyond the ovary and uterine cavity have powerful aromatase action enabling these abnormal cells to generate all the estrogen they need to stimulate cell proliferation and spread 274.
Aromatase is an enzyme that converts an androgen (Testosterone or Androstenedi0ne) to Estrogen. This then drives the spread of the endometrial tissue (Endometriosis) to various pelvic and other parts of the body.
Keeping estrogen levels down by ensuring the weight is optimal as deep visceral fat also has significant aromatase activity. Environmental factors also play a big part.
Key Points
The Estrogen Focus – Many factors can drive estrogen levels to increase. Many environmental factors are not obvious like perfumes and fragrances. Many pesticides and herbicides are hormone disrupters. These factors will be highlighted here
Beta-glucuronidase (an enzyme) activity – This activity can be checked by a gut microbiome analysis. Bowel organisms may split bound estrogen destined for excretion allowing the potent and dangerous estrogens to be reabsorbed putting anyone with a clinical problem that is sensitive to estrogen such as Endometriosis, Breast Cancer and Prostate Cancer in jeopardy. Beta-glucuronidase activity can be decreased by many dietary fibres and Calcium-D Glucarate (see below). Beta-glucuronidase activity in the gut can be measured using gut microbiome metagenomics and our Activ8Health practitioners can help organise this. The Cell Protect Anti-Inflammatory Formula below helps target this enzyme
Perfumes & Fragrances – These are essentially ubiquitous. From perfumes applied to the skin to 24/7 fragrances gushing out of a power plug-in container in various parts of a home, to hair products, toilet cleansers, makeup, lotions and potions added to the skin. Anything that smells nice is a phthalate which is a hormone disrupter and an estrogen mimic. One of the most important things to do is get a woman to cease all perfumes and fragrances in her environment.
Polyphenol-rich diets can be very protective of many cancers. Polyphenols are phytochemicals have been shown time and again in many research articles to protect against not only a number of cancers but also chronic disease states269.
The Cell Protect Anti-Inflammatory Formula contains a huge range of polyphenol wholefood compounds that include all the components of the POMI-T double-blind, placebo controlled trial (see below) and these include whole Pomegranate Powder, Turmeric (Curcumin), Green Tea Powder and Broccoli Powder. These four components have been fortified with other compounds shown to benefit those at risk of breast cancer.
Dietary management should be personalised and targeted
All disease states need dietary management that is targeted to them personally. Please check the Precision Nutrition tab for the least number of tests to manage a client
Important nutrient compounds in the fight against cancer
- Lignans are converted organisms in the gut microbiome to weak estrogens (Enterolactone and Enterodiol), and these weak estrogens compete at the estrogen receptor-blocking stronger estrogens from attaching.
Selenium has been shown to be protective against breast cancer. A maximum of x2 Brazil Nuts will provide a wealth of Selenium which has powerful antioxidant activity and is vital for selenium-containing enzymes like the many antioxidant enzyme systems like Glutathione Peroxidases 247. A maximum of x2 Brazil Nuts will provide a wealth of valuable health promoting Selenium.
Calcium D-Glucarate has been studied as a chemopreventative agent for many cancers as it is a natural inhibitor of
β-glucuronidase activity 64. Many gut organisms can produce β-glucuronidase an enzyme that undoes all the good work the liver has done, where excess oestrogens (or toxins) are excreted by attaching a molecule like Glucuronic Acid to a hormone like estrogen or to a xenobiotic, xenoestrogens, and other toxic compounds so they can be safely and inactively transported out of the body. Gut microorganisms that produce β-glucuronidase simply split the bound estrogen or toxin allowing it to be reabsorbed to carry out its toxic effects.
Omega-3 Essential Fatty Acids are vital to decrease inflammation in the body and cancerous or precancerous lesions. Metastatic spread is largely driven by inflammatory processes – the so-called ‘Malignant Flame130‘. At Activ8Health, we recommend a combination of high-dose DHA that will produce Resolvins that as the name suggests resolves inflammation. DHA is best taken as a supplement that has Choline (below)
Choline has been shown to have powerful anti-inflammatory effects that the brain can affect through the Acetylcholine released by the Vagus Nerve to dampen splenic inflammatory responses – the ‘Inflammatory Reflex5‘ Resveratrol – not only has strong aromatase inhibiting ability, it was also found to be a “potent inhibitor” of angiogenesis i.e. of new blood vessel formation that helps provide blood and oxygen to these spreading lesions 248.
Specific Supplement Options
9 Novel fibres to provide dietary fibre diversity. Click the button to find out more
Partially Hydrolysed Guar Gum (PHGG)
Strongly consider for anyone with Breast, Prostate, Bowel and Pancreatic Cancer in addition to the Activ8Health Multifibre Blend
This is a safe and effective soluble fibre that has been extensively researched. The guar gum is pre-digested enzymatically to produce smaller molecules. PHGG significantly increases Bifidobacteria and Lactobacilli and helps stimulate Butyrate an important compound for gut health
Beta-Glucuronidase Bacteria (Gut Microbiome Analysis)
Significantly decreased by Partially Hydrolysed Guar Gum (Relie Fibre)
Finding that your gut microbiome is primed to produce Beta-Glucuronidase an enzyme that can allow estrogen bound for excretion to be reabsorbed in the body and also releases other toxic compounds locally in the bowel putting anyone at risk for cancer of the breast, prostate and also bowel cancer. Beta Glucuronidase activity was 12.1 times higher than controls in those with bowel cancer272. There are associations with pancreatic cancer as well. Partially Hydrolysed Guar Gum (Relie Fibre) was shown to significantly decrease Beta Glucuronidase activity271.
Anyone with Breast, Prostate, Colon and Pancreatic Cancer
Should strongly consider adding more Partially Hydrolysed Guar Gum and used with the Activ8Health Multifibre Blend
Anthocyanin & Polyphenol-Rich-Blend - Powerful Plant compounds
That polyphenols can have powerful effects on health is incontrovertible. However, the Western diet has very poor levels of these important compounds. This potent blend of Premium New Zealand Purple Carrots + Premium Australian Blue Berries and Premium Turkish Pomegranates pack a polyphenol punch. Polyphenol-rich diets have been shown to decrease the risk of Cardiovascular (Heart & Vascular) disease, many cancers and neurodegenerative disorders like Alzheimer's Disease (AD) and Parkinson's Disease273.
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Mix in smoothies, dilute fruit juice and yoghurt |
Cell-Protect-Anti-Inflammatory-Formulation
For many inflammatory conditions
The POMI-T Trial a double-blind, placebo-controlled trial was a game-changer in the management of prostate cancer and in lowering PSA
This formulation has not only the full polyphenol components of the POMI-T Study (Pomegranate, Turmeric, Green Tea and Broccoli) it has added Boswellia (blocks LOX-5 and the production of LTB4) and Boron (protective of prostate and breast cancer), Resveratrol, Lignans, Calcium-D-Glucarate (blocks deconjugation of oestrogen in the bowel) and is as a powerful combination to protect the breast, prostate and a multitude of other disease states driven by inflammation.
Thus in this formulation there are a multitude number of natural compounds that have been shown to fight inflammation.
Supporting Supplement Options
| Anti-Inflammatory Compounds Opposite |
Magnesium Big-4 Combo View the 4 forms of Magnesium in this popup button
Magnesium can lower blood pressure so start off with a low dose like one at night then two at night |
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DHA + Choline Inflammation is a driver of Insulin Resistance and Diabetes. This needs to be addressed by DHA, EPA and Choline. Please order an Omega-3 Index to take the guesswork out of this. DHA + EPA are vital to producing RESOLVINS that as the name suggests, resolve inflammatory processes intrinsically involved in many disease states. Maximum 2 Capsules BD |
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Extra DHA and EPA - EFA Essentials Provide enough Omega-3's to levels of 4 - 5 gram daily for 4 - 6 months then recheck the Omega-3 Index to see if tissues levels are optimal. The client can then go onto a maintenance dose and this saves money
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| N-Acetyl Cysteine
That many chronic diseases including insulin resistance have an increased need for antioxidants is undeniable. Disease processes produce far more demand for nutrient resources for repair processes and a Western Diet is pathetically low in many micronutrients. Cysteine will need to be constantly replenished to meet the demands of Glutathione and low intracellular Glutathione levels have been established in Diabetics 17. Oral NAC effectively boosts intracellular Glutathione levels to fight oxidative stress and dampen inflammatory processes
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| Opti-D3 + K2
Vitamin-D has proven anti-inflammatory modulation effects Both Vitamin-D 21 and Vitamin-K 48 are strongly associated with insulin sensitivity with a new mechanism shown for Vitamin-K2 to improve mitochondrial function and utilization of glucose for energy production through SIRT1 signalling.
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Magnesium should be taken at night as it can make people sleepy - not a bad thing for people who find it hard to go to sleep
Choose one of the following for your client based on their clinical history
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MICRONUTRIENTS ARE CRITICAL FOR CELLULAR AND MOLECULAR REACTIONS CHOOSE ONE BASED ON YOUR CLIENTS NEEDS
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GenoMULTI-ACTIVE-B First Choice For:
Numerous benefits of this choice from Vitamin-K2 (MK7) not found in many preparations to Choline protective against fatty liver and alcohol liver toxicity to Mixed Vitamin-E Tocopherols, Mixed Citrus Bioflavonoids that have Lutein for eye health to Resveratrol. This formulation also has 130 mcg of Potassium Iodide and Selenium for Thyroid health including biologically active Vitamin-B forms and critical Mineral Chelates. Has iron - thus avoid in anyone with HFE Haemochromatosis genes but this formulation is suitable for most people Use for those who want - Energy, neuroprotection, to decrease homocysteine and to protect the bones, a health methylation system, a healthy stress response
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BioTress First Choice For:
Does not contain Iron
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| Micronutrient Sufficiency
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Opti Vital - Multivitamin with Nicotinic Acid First Choice for:
Choose this Multi-V for anyone with a risk of Cardiovascular disease i.e., high lipids or prediabetes or diabetes Contains low-dose iron Nicotinic Acid (not Nicotinamide) supports improved blood lipid profiles There is a two-fold increased risk of cardiovascular disease in insulin resistant states 15. Stroke is a common cause of morbidity and mortality in diabetes Using a Multivitamin that is designed with cardiovascular disease in mind is prudent to meet the extra micronutrient demands for cellular biochemistry, repair processes and metabolism |
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Natal Care (Pre-Pregnancy, Pregnancy and After Birth) Choose this Multi-V for anyone with thyroid issues as it has thyroid support levels of iodine and selenium This is usually suggested for anyone who is of childbearing age for both partners but is a generally good Multivitamin & Mineral formulation for anyone |
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Anti-inflammatory Support Supplements