Button-Magnesium-Big-4-Related

Fig.1

This is an extremely important concept to understand. Why Magnesium is not used as a knee-jerk reaction to anyone with prediabetes or diabetes or for that matter hypertension which can be a part of the Metabolic Syndrome an Insulin Resistant (IR) state is a mystery.

What happens with low magnesium levels is that there is increased renal excretion and this renal excretion leads to lower and lower Magnesium levels and this in turn lowers intracellular Magnesium which is critical for insulin signalling making Insulin Resistance (IR) worse. An absolute vicious cycle if ever there was one. 

“Moreover, insulin receptor autophosphorylation is dependent
on intracellular Mg2+ concentrations, making Mg²⁺ a direct factor in the development of insulin resistance. Conversely, insulin is an important regulator of Mg²⁺ homeostasis. In the kidney, insulin activates the renal
Mg²⁺ channel transient receptor potential melastatin type 6 that determines the final urinary Mg²⁺ excretion¹¹“

Critical flaws in research such as this study which stated categorically that a 12 week trial showed that magnesium supplementation did not work²⁵⁹. This shows flawed thinking in nutrient research where nutrients are supposed to work like magic bullets i.e., instantaneously like drugs in an Accident & Emergency Dept. This is simply foolish. Dietary and nutrient management need far longer time-frames of 20 – 40 weeks to reach steady state²⁶⁰. As the authors of this study states, it is time for a reappraisal of the use of magnesium in so many states that are exacerbated by hypomagnesaemia but where flawed research has tainted the minds of practitioners. There are vast pools of magnesium intracellularly, in bone (60%) and intracellular spaces (40%) thus serum magnesium is a very unreliable marker of Magnesium status. These pools will avidly take up supplemented Magnesium so it will take time, a great deal of time to reach a steady state²⁶⁰.

A high Calcium intake and low Magnesium intake will make matters worse in terms of intracellular Mg ²⁺levels and high intracellular Ca²⁺ trigger NFkB and inflammatory changes⁷⁷.

• Researched at the Massachusetts Institute of Technology (MIT) with a Nobel Laureate as a part of the team
• The Threonate component is a derivative of Vitamin-C
• This form crosses the Blood Brain Barrier (BBB)

• Shown to help with anxiety
• Shown to be of benefit in many conditions including high blood pressure, stroke, heart rhythms, fibromyalgia, pain syndromes, all cause mortality, Type-2 Diabetes Mellitus ⁶⁵.

• Magnesium Orotate is a chelate of Magnesium + Orotic Acid
• It is interesting some people use this form for the benefits of Magnesium
• Others take this chelate form of Magnesium for the Orotic acid used in sports for endurance and heart health

• A great all-round magnesium that helps build up Magnesium levels throughout the body
• Helping to decrease arterial wall stiffness and lowering blood pressure ⁶⁵.

Low Magnesium sets into motion this series of events that you will recognise as being some of the most common presentation in General Practice and medicine in general ⁴⁴.

1. Low Magnesium levels switch off Tyrosine Kinase needed to turn ‘on’ the Insulin receptor and insulin signalling
2. When Insulin Signalling is disrupted, you have Insulin Resistance and when this happens, blood glucose levels increase causing widespread damage (Glycation)
3. Insulin Resistance will cause Beta Cell Burnout eventually
4. Low Magnesium creates a dysfunctional Na-Mg Exchanger protein ⁴⁴ and this allows a disproportionate amount of Sodium (Na) and Calcium (Ca) to enter the cells
5. High intracellular Sodium and Calcium lead to hypertension and inflammation setting the scene for cardiovascular disease and Coronary Artery Calcification (CAC)
6. Magnesium is a natural antagonist for Calcium – a natural Calcium Channel Blocker. So low levels of Magnesium allows Calcium to predominate and if there is also low Vitamin-K1/K2 levels, then Calcium will enter soft tissues and cardiac valves. Why would there be a Low Vitamin-K1/K2 level? Well 99% of the Australian population does not get their recommended intakes of Veggies and Fruit!!!